Pregled bibliografske jedinice broj: 193591
Trinitrobenzenesulfonic acid-induced colitis in interferon-gamma knock-out mice
Trinitrobenzenesulfonic acid-induced colitis in interferon-gamma knock-out mice // World Congres of gastroenterology abstract book / ... (ur.).
Bangkok: ..., 2002. (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 193591 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Trinitrobenzenesulfonic acid-induced colitis in interferon-gamma knock-out mice
Autori
Veljača Marija ; Ševeljević-Jaran Daša ; Rogulja Ana ; Brajša Karmen ; Guglijetta Antonio
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
World Congres of gastroenterology abstract book
/ ... - Bangkok : ..., 2002
Skup
WCOG 2002
Mjesto i datum
Bangkok, Tajland, 29.02.2002. - 02.03.2002
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
interferon gamma knock out mice; IBD
Sažetak
IBD is chronic relapsing inflammatory condition of the gut. The etiology of IBD remains unclear ; its treatment is still not a curative one. Interferon gamma was thought to be a potent pro-inflammatory cytokine involved in the pathogenesis of human disease and animal models to IBD. Several studies were performed in mice with disrupted interferon gamma gene or receptor suggesting that this cytokine is not neccesary for the induction of colitis. The aim of this study was to investigate the role of interferon gamma in the development of TNBS-induced colitis using inteerferon gamma knock-out C57BL and Balb/c mice. C57/BL mice, both KO and WT do not develop colitis after single intracolonic administration of 25 mg/kg TNBS dissolved in 50% ethanol. Higher mortallity rate observed in WT than in KO at 25 mg/kg TNBS dissolved in 40% ethanol suggest regulatory role of inteeferon-gamma.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
