Naslov
The crystal structure of copper insulin derivative

Autori
Prugovečki, Biserka ; Matković-Čalogović, Dubravka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XIX. Croatian Meeting of Chemists and Chemical Engineers : Knjiga sažetaka / Hrvatsko kemijsko društvo i hrvatsko društvo kemijskih inženjera i tehnologa - Zagreb, 2005, 136-136

Skup
XIX. Croatian Meeting of Chemists and Chemical Engineers

Mjesto i datum
Opatija, Hrvatska, 24.04.2005. - 27.04.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
bakrov derivat inzulina; kristalna struktura
(copper insulin derivative; crystal structure)

Sažetak
Although insulin is accumulated in the pancreas as zinc containing hexamer, it is active as a monomer that does not contain zinc. Seventy years ago it was discovered that other metals (Co, Ni and Cd) can replace the zinc ion 1 , but so far only one paper describing coordination of some other metal  2 in insulin has been published so far. Single crystals of the insulin derivatives with copper have been prepared by the hanging drop vapour diffusion crystallisation method at pH=6, 4. 2-Cu insulin derivative crystallizes in the trigonal system (with hexagonal axes) with the cell parameters a = 81, 560 &Aring ; ; , c = 33, 747 &Aring ; ; . Structure was refined to the uncertainty factor R=0, 1581 for 24899Fo>4 (Fo) i R(free)=0, 2096 for 1348Fo>4 (Fo) using SHELXL97 program. 2-Cu hexamer contains two copper ions octahedrally coordinated by three His B10/ His D10 NE2 imidazole ligands and three water molecules.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA