Naslov
Nove beta-ciklodekstrinske vezikule
(Novel beta-cyclodextrin vesicles)

Autori
Frkanec, Leo ; Darcy, Raphael

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XIX. hrvatski skup kemičara i kemijskih inženjera : knjiga sažetaka / Škare, Danko - Zagreb : Sveučilišna tiskara, 2005, 107-107

Skup
XIX. hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Opatija, Hrvatska, 24.04.2005. - 27.04.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
ciklodekstrini; vezikule; nanočestice; prijenos lijekova ili gena
(cyclodextrins; vesicles; nanoparticles; drug or gene delivery)

Sažetak
The ability of cyclodextrins (CDs) to act as hosts to apolar guest molecules by including them in their hydrophobic cavities is well established. Increasingly, the native CDs now serve as scaffolds on which multiple functional groups can be assembled with controlled geometry. This has opened new areas of supramolecular chemistry assemblies with possibilities for drug or gene delivery [1]. Amphiphilic beta-cyclodextrins, substituted with hydrophobic n-alkylthio chains at the primary hydroxyl side and hydrophilic oligo(ethylene glycol) units at the secondary side, form bilayer vesicles or nanoparticles with a diameter from 30 to 120 nm (depending on the length of the alkyl chain) [2, 3]. We have now prepared a new class of amphiphilic -CD derivatives substituted with hydrophobic n-alkylthio chains at the secondary hydroxyl side and hydrophilic oligo(ethylene glycol) units at the primary side (Figure). These compounds, 1 and 2, can form uniform bilayer vesicles in water approximately 230 and 150 nm in size, respectively.

Izvorni jezik
Hrvatski

Znanstvena područja
Kemija

POVEZANOST RADA