Naslov
Sinteza novih acikličkih i epoksidnih nukleozidnih analoga
(Synthesis of the novel acyclic and epoxide nucleoside analogues)

Autori
Krištafor, Vedran ; Raić-Malić, Silvana ; Mintas, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga sažetaka = Book of abstracts / XIX. hrvatski skup kemičara i kemijskih inženjera / Rapić, Vladimir ; Rogošić, Marko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Hrvatsko kemijsko drustvo, 2005, 145-145

Skup
XIX. hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Opatija, Hrvatska, 24.04.2005. - 27.04.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
aciklički i epoksidni nukleozidni analozi; hidrazinoliza; 1H i 13C NMR
(acyclic and epoxide nucleoside analogues; hydrasinolysis; 1H and 13C NMR)

Sažetak
As a continuation of our previous research on purine derivatives of 1-aminocyclopropane-1-carboxylic acid and 1-amino-1-hydroxymethylcyclopropane [1], we have synthesized some new nucleoside analogues with unsaturated acyclic and epoxide side chains. The principal aim of this study is evaluation of the novel compounds on their antitumor and antiviral activities. Both cis and trans series of nucleoside analogues were synthesized by reactions of purine or pyrimidine bases and appropriate cis or trans precursors. Structures of the novel compounds and cis or trans configuration of the double bonds and epoxide rings were deduced from 1H and 13C NMR spectra by analyses of chemical shifts, H-H coupling constants and connectivities in two-dimensional heteronuclear correlation spectra

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA