Naslov
Regulation of manganese accumulation in perinatally exposed rat pups

Autori
Kostial, Krista ; Blanuša, Maja ; Piasek, Martina

Izvornik
JAT. Journal of applied toxicology (0260-437X) 25 (2005); 89-93

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
manganese; placental transfer; mammary transfer; neurotoxic risk; cross-fostering; iron; zinc; calcium; perinatal period; pups

Sažetak
The risk of manganese (Mn)-related ill effects in neonate has been the topic of several investigations because in formula-fed infants Mn intake is much higher than in breast-fed ones. In young when Mn homeostasis is not yet developed, increased Mn intake might pose neurotoxic risk. Our work aimed at collecting new data on Mn accumulation during the perinatal period by using an experimental model in pups whose mother rats were orally exposed to Mn in drink (as chloride, dose 2000 ppm Mn) throughout pregnancy and 11-days of lactation. Pups were cross-fostered at birth and placental and mammary transfer of Mn at birth and at the age of 11days were evaluated. Total pup body burden of Mn was analysed by atomic absorption spectrometry. Concentrations of iron (Fe), zinc (Zn) and calcium (Ca) were also analysed at the end of the experiment. Concentration of Mn in perinatally exposed pups was 6-8 times higher than in controls irrespective of the period and duration of exposure. After cessation of exposure, Mn concentration decreased almost to control levels. Concentration of other essential elements (Fe, Zn, Ca) were not affected by Mn exposure. Our results indicate existence of an accurate regulation of Mn accumulation in pups exposed to Mn during the perinatal period.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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