Naslov
Effects of nimodipine, felodipine and amlodipine on electroconvulsive shock-induced amnesia in the rat

Autori
Župan, Gordana ; Vitezić, Dinko ; Mršić, Jasenka ; Matešić, Damir ; Simonić, Ante

Izvornik
European journal of pharmacology (0014-2999) 310 (1996); 103-106

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
electroconvulsive shock; amnesia; nimodipine; felodipine; amlodipine; rat

Sažetak
The effects of various doses (0.03, 0.1 or 1.0 mg/kg) of the Ca2+ channel blockers nimodipine, felodipine and amplodipine on the learning ability of rats exposed to electroconvulsive shock were examined. The animals were trained in a passive avoidance procedure. The drugs tested were injected 30 min before the learning trial started. The electroconvulsive shock was given immediately after the learning trial response had been acquired. A passive avoidance retention test was performed 24 h later. It was found that electroconvulsive shock strongly impaired the retention of the passive avoidance response. Nimodipine, felodipine and amplodipine did not influence the passive avoidance behavior in the sham electroconvulsive shock group, but significantly improved the retention deficits in the animals exposed to electroconvulsive shock. These findings support the hypothesis that perturbations in Ca2+ homeostasis can contribute to the memory deficits associated with electroconvulsive shock. The antiamnestic effects of the substances tested make them interesting candidates for clinical trials in patients with cognitive impairment caused by electroconvulsive shock therapy.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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