Naslov
Effects of nicardipine, felodipine and nifedipine on passive avoidance behavior of intact and hypoxia-exposed rats

Autori
Župan, Gordana ; Mršić, Jasenka ; Simonić, Ante

Izvornik
Archives internationales de pharmacodynamie et de thérapie (0003-9780) 325 (1993), 1/2; 61-69

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
passive avoidance behavior ; hypoxia ; nicardipine ; felodipine ; nifedipine ; rat

Sažetak
The effects of various doses (0.03, 0.1, 0.3 or 1 mg/kg) of the calcium channel blockers nicardipine, felodipine and nifedipine on the learning ability in intact rats and on hypoxia-induced retention deficits were examined. All animals were trained in a passive avoidance procedure. The drug tested had been injected 30 minutes before the learning trial started. Some animals were exposed to a hypoxic condition immediately after the learning trial response had been acquired. A passive avoidance retention test was performed 24 hours later. It was found that hypoxia strongly impaired the retention of the passive avoidance response. Nicardipine, felodipine and nifedipine did not influence the passive avoidance behavior in the intact animals, but significantly improved the retention deficits in the animals exposed to hypoxia. The effects of the substances tested were dose-dependent. These findings support the hypothesis that perturbations in calcium homeostasis can contribute to the memory deficits associated with hypoxic conditions.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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