Naslov
The effect of adamantyl derivative TAMORF in soman poisoned rats

Autori
Radić, Božica ; Lucić Vrdoljak, Ana ; Peraica, Maja ; Žlender, Vilim ; Fuchs, Radovan ; Bradamante, Vlasta

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Programme and presentation abstracts of 4th SISPAT international symposium on protection against toxic substances / - Singapur : Aplied science and analysis, 2004, 113-113

Skup
4th SISPAT international symposium on protection against toxic substances

Mjesto i datum
Singapur, 06.12.2004. - 10.12.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
soman; adamantanes; therapy

Sažetak
Although the basic mechanisms of toxicity of the highly toxic nerve agents has been known for a long time, there are still major problems with the effective treatment of acute poisoning by them, especially by soman. The objective of this study was to evaluate the efficacy of tamorf (a new synthesized adamantyl derivative containing morpholine group) on rats poisoned with soman. In this study rats given subcutaneously &frac14 ; ; and &frac12 ; ; LD50 of soman were treated intraperitoneally with tamorf (2.5 mg/kg b.w.) before or after soman injection. Catalytic activity of acethylcholinesterase (AChE) was measured in plasma and brain at different time periods from 10 minutes up to 24 hours after application of soman. Tamorf was applied alone or together with atropine sulphate (10.0 mg/kg b.w.). The best effect of tamorf in rats given &frac14 ; ; LD 50 of soman was obtained when it was given as pre-treatment together with atropine. Treatment with tamorf increased the catalytic activity of AChE in plasma and brain of all soman poisoned rats, except when given up to 10 minutes after &frac12 ; ; LD 50 of soman. Our results suggest that the treatment with tamorf together with atropine antagonise the acute toxicity of soman, and could be supplementary therapy in soman poisoning.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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