Naslov
Neurotransmitter Changes in Alcoholism and in the Withdrawal Syndrome (Neruobiological Tests of Alcoholism)

Autori
Buljan, Danijel ; Brzović, Z. ; Thaller, Vlatko ; Breitenfeld, Darko ; Marušić, Srđan

Izvornik
Collegium antropologicum (0350-6134) 19 (1996), 1; 175-182

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
Alcoholism; Withdrawal syndrome; Neurottransmitter changes

Sažetak
In this paper, we show the results of the investigation dealing with the neurobiological markers of alcoholism in the group of 39 alcoholics suffering from the withdrawal syndrome (WS), compared to the results of the group of 39 alcoholics showing no signs of the withdrawal syndrome. The groups examined differ by age, duration of the continuous drinking, daily amount of the alcohol consumption (g) and tolerance to alcohol. All clinical disturbances prevail in the group of alcoholics with the withdrawal crisis. The incidence of individual findings was compared by means of &#61539; 2 test and by means of Poissonś comparison of proportions for the independent groups, with the statistical significance set at p<0.05. The increased values of epinephrine were observed in 36 (93, 32%) of alcoholics with WS and 37 (94, 88%) without WS, norepinephrine values were increases in 33 alcoholics (84, 61%) with WS and 35 (89%) without WS. Serotonine values are decreased in 35 (89, 75%) subjects with WS and 34 (87, 18%) subjects without WS. 5-HIAA values were increased in 4 (10, 25%) subjects with WS and 5 (12, 82%) subjects without WS, and all other subjects in both groups showed lower values, though inside the normal margins. By means of laboratory testing, very high sensitivity of epinephrine (94, 99%), norepinephrine (84, 61%) and serotonine (89, 75%) test was determined for both groups of subjects.

Izvorni jezik
Engleski

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