Naslov
Cancer micrometastasis detection and destruction using antibody coated superparamagnetic nanoparticles induced hyperthermia. Current state of the art and perspectives of applications in the the prostate metastatic cancer"
(Cancer micrometastasis detection and destruction using antibody coated superparamagnetic nanoparticles induced hyperthermia. Current state of the art and perspectives of applications in the the prostate metastatic cancer)

Autori
Sabolović, Domagoj ; Cesar de Morais, Paulo ; da Silva, Maria de Fatima ; Barbić, Jerko ; Mori, Takeo ; Tucak, Antun

Izvornik
Medicinski vjesnik (0350-6487) 36 (2004); 37-41

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
Supermagnetic nanoparticles; micrometastasis; prostate; magnetothermolysis; alternative magnetic field; in vivo cell targeting

Sažetak
Biomedical application of nanotechnology, such as early, in vivo disease detection and malignant cell destruction, were documentated using a small sized supermagnetic particles coated with specific antibodies. Antibody coated nanoparticles can be used as a contrast markers in magnetic resonance imaging of targeted cells and at the same time in temeprature induced specific destruction of these cells in situ, using external aletrnative magnetic field. Our experimetal results corroborate this hypothesis. Combined diagnosis with treatment, many considerable applications of nanotechnology in biomedicine could be performe, depending on availability of appropiate antibodies. This paper describes strategy for future developments and multidisciplinary approach involved in the preparation and handling of nanoparticles and experimental design.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA