Pregled bibliografske jedinice broj: 191761
Theoretical study of enzyme specificity and selectivity
Theoretical study of enzyme specificity and selectivity // Regional Biophysics Meeting 2005: Book of abstracts / Abramović, Zrinka (ur.).
Zreče, Slovenija: Slovenian Biophysical Society, 2005. str. 10-10 (pozvano predavanje, nije recenziran, sažetak, znanstveni)
CROSBI ID: 191761 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Theoretical study of enzyme specificity and selectivity
Autori
Tomić, Sanja
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Regional Biophysics Meeting 2005: Book of abstracts
/ Abramović, Zrinka - : Slovenian Biophysical Society, 2005, 10-10
Skup
Regional Biophysics Meeting 2005
Mjesto i datum
Zreče, Slovenija, 16.03.2005. - 20.03.2005
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Nije recenziran
Ključne riječi
biophysics; Computer modelling; complex biosystems
Sažetak
Theoretical study of enzyme specificity and selectivity Enzymes are important molecules for drug design and biocatalysis. We are developing simple, physically based methods to study their affinity and specificity. Starting from the experimental crystal structures we model enzyme mutants and their complexes with substrates and inhibitors. In order to find relationships between their structure and specificity and/or selectivity we, using different statistical methods, correlate results of kinetic and thermodynamic measurements with data obtained by molecular modelling. Results of our study on Burholderia cepacia lipase (BCL) lipase stereoselectivity and Ras proteins specificity will be presented.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
