Naslov
Clinical relevance of the serum dipeptidyl peptidase IV (DPP IV/CD26) activity in adult patients with Crohn's disease and ulcerative colitis

Autori
Varljen, Jadranka ; Mijandrušić Sinčić, Brankica ; Batičić, Lara ; Varljen, Neven ; Detel, Dijana ; Lekić, Andrica

Izvornik
Croatica chemica acta (0011-1643) 78 (2005), 3; 427-432

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
dipeptidyl peptidase IV (DPP IV/CD26); Inflammatory bowel disease; Crohn’ s disease; Ulcerative colitis

Sažetak
The dipeptidyl peptidase IV (DPP IV/CD26), a serine-type protease, is a membrane-anchored enzyme widely expressed in many cell types. DPP IV is also present in a soluble form in the serum. The aim of this study was to evaluate the clinical relevance of the changes in serum DPP IV activity in adult patients with inflammatory bowel diseases-IBD (Crohn&#8217; s disease-CD and Ulcerative colitis-UC). Both serum DPP IV activities in patients with CD (36, 83 &#177; ; ; ; 9, 74) U/l and UC (33, 87 &#177; ; ; ; 10, 69) U/l were statistically significantly decreased compared with healthy controls (48, 37 &#177; ; ; ; 8, 94) U/l, (p<0, 001). Values correlated inversely with the disease severity for both diseases. No statistically significant difference in the serum DPP IV activity in patients with CD and UC was found and therefore it could not be a good marker for the differential diagnosis. However, it appears to be useful as an available, non-invasive marker in the diagnosis of disease activity.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

POVEZANOST RADA