Naslov
Compartmentalization of growth factor receptor signalling

Autori
Hoeller, Daniela ; Volarević, Siniša ; Đikić, Ivan

Izvornik
Current opinion in cell biology (0955-0674) 17 (2005); 107-111

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Signalling; compartmentalization; growth factor receptors; ribosomes; signalling and selective translation; diseases

Sažetak
Spatial and temporal separation of signal transduction pathways often determines the specificity in cellular responses. Recent advances have improved our understanding of how growth factor signalling is influenced by the formation of molecular complexes (signalosomes) in distinct cellular compartments. There has also been new insight into the mechanisms that determine the signalling competence of these complexes and their role in receptor endocytosis, retrograde trafficking in neurons and restricted protein biosynthesis, and many examples have been found where signalosome deregulation leads to disease.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA