Naslov
Ekspresija Heat Shock proteina 70 u tkivu sluznice usne šupljine kod oralnog lihen rubera
(Expression of Heat Shock Protein 70 in Mucosa of Oral Lichen Ruber)

Autori
Arnautović, Milan ; Pirkić, Ahmed ; Cekić-Arambašin, Ana ; Biočina-Lukenda, Dolores

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts of 1st Dental Congress of Bosnia and Herzegovina with International Participation / Sulejmanagić, Halid ; Vlaški, Savo - Sarajevo : School of Dentistry, University of Sarajevo, 2001, 166-166

Skup
1st Dental Congress of Bosnia and Herzegovina with International Participation

Mjesto i datum
Sarajevo, Bosna i Hercegovina, 17.10.2001. - 20.10.2001

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
heat shock protein 70; oralni lichen ruber; imunohistokemija
(heat shock protein 70; oral lichen ruber; immunohistochemistry)

Sažetak
INTRODUCTION: Oral lichen planus is a chronic inflammatory mucosal disease of unknown etiology that appears clinically as persistent red, white or mixed lesions. Cell-mediated immune mechanism seem to play the main role in pathogenesis of OLP. The most possible way of disease development is an alteration of keratinocytes caused by external factors. This is followed with a local immunological response. In recent years, heat shock proteins (HSP) of oral mucosa have been investigated as potential autoantigens. AIM: The aim of the study was to detect expression of HSP 70 in keratinocytes in group of OLP patients and in control group using immunohistochemical method. The intensity and distribution of HSP 70 in oral mucosa of both groups were also compared. MATERIAL AND METHODS: Patients with clinically diagnosed and histologically confirmed OLP have been examined. Clinical parameters of disease were measured. Tissue expression of HSP 70 in bioptic specimens was determined using LSAB method. Visualization was made by DAB. Persons with healthy oral mucosa were used as control group. RESULTS: The study presents topography and intensity of expression of HSP 70 in cellular constituents of oral mucosa, especially in keratinocytes. Findings of altered HSP 70 in OLP patients suggest pathogenetic connection between development of OLP and expression changes of cellular HSPs.

Izvorni jezik
Engleski

POVEZANOST RADA