Naslov
Glutathione-transferase as potential diagnostic factor in gynecological tumors: A preliminary note

Autori
Osmak, Maja ; Babić, Damir ; Abramić, Marija ; Miličić, Duško ; Bizjak, Lidija ; Beketić-Orešković, Lidija ; Ćepulić, Egidio ; Orešković, Slavko ; Jukić, Stanko ; Eljuga, Damir

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Proceedings of the Croatian-Slovenian meeting: Molecular oncology today / Osmak, Maja ; Škrk, Janez - Zagreb : Croatian league against cancer, Kratis, 1996, 81-84

Skup
Croatian-Slovenian meeting: Molecular oncology today

Mjesto i datum
Zagreb, Hrvatska, 19.12.1995

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
gynecological tumors; glutathione; glutathione transferase; diagnostic factor

Sažetak
The major problem in cancer therapy is drug resistance. Resistance to alkylating agents may involve glutathione (GSH) and glutathione S-transferase (GST), as suggested by in vitro studies. The present paper examines GSH level and GST activities in 34 samples of gynecological tissues: 25 samples of corpus uteri and 9 samples of the ovary, which include: normal tissues, benign tumors and malignant tumors. We found similar or even lower levels of GSH in benign and malignant tumors as compared to normal tissues. For malignant tumors of corpus uteri and ovary, however, we obtained higher GST activities than in normal tissues. As higher GST activities may contribute to resistance of tumor cells to chemotherapy with alkylating agents and doxorubicin, they may serve as a diagnostic factor for tumors.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA