Naslov
Reaction of hydroxyurea with iron(III): Products and the stoichiometry of the redox reaction

Autori
Kujundžić, Nikola ; Nigović, Biljana ; Sanković, Krešimir

Izvornik
Zeitschrift für anorganische und allgemeine Chemie (0044-2313) 630 (2004), 15; 2749-2753

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Hydroxyurea; Mono(hydroxyureato)iron(III) complex; Redox reaction; Hydroxyurea radical
(Hydroxyurea; Monohydroxyureato)iron(III) complex; Redox reaction; Hydroxyurea radical)

Sažetak
Products and reaction stoichiometry of the interaction between iron(III) and hydroxyurea (HU) in aqueous solutions were studied. Under condition of an excess of iron(111) over hydroxyurea, initially formed mono(hydroxyurea)iron(III) complex decomposed through redox processes, forming two moles of Fell, one mole of NH4+, one mole of CO2, and 0.5 mole of N2O per 1 mole of initially present HU. Hydroxyurea radical, H2N-CO-NHO., was detected in the course of the reaction. The possible mechanism of the formation of the products is discussed and compared with that obtained for horseradish peroxidase mediated oxidation of hydroxyurea with hydrogen peroxide. The possibility of direct reaction of hydroxyurea with the iron center of protein R2 of the ribonucleotide reductase is proposed. The reaction examined may serve as a simple model for testing the suggested hydroxyurea like activity for chemical substances.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

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