Naslov
Quinuclidinium derivatives as inhibitors of cholinesterases, reactivators of the phosphorylated enzymes and antidotes against poisoning by organophosphates

Autori
Simeon-Rudolf, Vera ; Reiner, Elsa

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Proceedings of the Fifth Chemical and Biological Medical Treatment Symposium / Brodbeck, Urs - Aberdeen (MD) : Applied Science & Analysis, 2004, 303-307

Skup
The Fifth Chemical and Biological Medical Treatment Symposium

Mjesto i datum
Spiez, Švicarska, 25.04.2004. - 30.04.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
quinuclidinium compounds; oximes; antidotes; soman; tabun; protection; reactivation; therapy

Sažetak
Many quinuclidinium derivatives have been recognized as pharmaceutical agents and several were tested in the therapy of animals poisoned by organophosphorus compounds. Thirteen quinuclidinium derivatives were prepared in Croatia over the past seven years meant for testing their interaction with cholinesterases as well as their antidotal potency in poisoning of animals by organophosphorus compounds. They are quaternized monoquinuclidinium derivatives or their conjugates with another quaternized quinuclidinium, pyridinium or imidazolium ring. Three compounds have two oxime groups, seven are monooximes and three compounds do not bear an oxime group. The compounds were analyzed in their reaction with acetylcholinesterase in vitro and in their antidotal impact in vivo against poisoning by soman and tabun. The properties of the compounds concerning the above parameters were compared with those of the four standard oximes PAM-2, Toxogonin, HI-6 and TMB-4.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA