Pregled bibliografske jedinice broj: 187609
Review of some oximes as antidotes against experimental organophosphate poisoning
Review of some oximes as antidotes against experimental organophosphate poisoning // Proceedings of the Fifth Chemical and Biological Medical Treatment Symposium / Brodbeck, Urs (ur.).
Aberdeen (MD): Applied Science & Analysis, 2004. str. 255-262 (predavanje, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)
CROSBI ID: 187609 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Review of some oximes as antidotes against experimental organophosphate poisoning
Autori
Reiner, Elsa ; Simeon-Rudolf, Vera
Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni
Izvornik
Proceedings of the Fifth Chemical and Biological Medical Treatment Symposium
/ Brodbeck, Urs - Aberdeen (MD) : Applied Science & Analysis, 2004, 255-262
Skup
The Fifth Chemical and Biological Medical Treatment Symposium
Mjesto i datum
Spiez, Švicarska, 25.04.2004. - 30.04.2004
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
acetylcholinesterase; oximes; organophosphate poisoning; protection
Sažetak
The paper summarizes in vitro and in vivo studies on selected pyridinium, imidazolium and quinuclidinium oximes, which were prepared as antidotes against warfare agents, particularly against Tabun and Soman. In vitro studies comprised binding of oximes to native acetylcholinesterase and reactivation of the phosphylated acetylcholinesterase. The antidotal effect was tested on mice or rats by determining the therapeutic factor when the oximes (plus atropine) were applied immediately after the organophosphorus compound.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
0022014
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb
