Naslov
Comparability of multiple sclerosis and chronic relapsing experimental allergic encephalomyelitis. II. Immunologic observations

Autori
Morović, Miro ; Rukavina, Daniel ; Sepčić, Juraj ; Eberhardt, Predrag ; Ledić, Darko ; Haller, Herman

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Periodicum Biologorum. Volumen 88. Supplementum 1/A / - Zagreb, 1986, 335-336

Skup
First Congress of the Yugoslavian Immunology Society

Mjesto i datum
Opatija, Hrvatska, 21.10.1985. - 25.10.1985

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Multiple sclerosis; Chronic Relapsing Experimental Allergic Encephalomyelitis; T-lymphocytes

Sažetak
Our longitudinal studies in MS patients and animals suffering from chronic relapsing experimental allergic encephalomyelitis (CR-EAE) illustrate some changes in the lymphocytic behaviour during different periods of disease activity. Lymphocyte subpopulations in peripheral blood were identified by the rosette forming method. There was a statistically significant decrease in active T-lymphocytes in MS patients with the active disease versus patients with the stable disease (P<0, 05) and healthy controls (P<0, 001). Our results are consistent with the idea that some of the T-cells could migrate to the CNS where their proliferation and activation probably take place. Cellular immunity during various stages of CR-EAE in F1 (AO x DA) rats was assessed by a delayed-type skin sensitivity to the CNS-antigen. The diameter of the erythema and induration was measured at 24-48 hours after being challenged. Controls groups were non-treated. A highly positive delayed-type skin reaction developed in the latent period of CR-EAE (preacute stage). In contrast, the delayed skin reaction declined to a normal level in the acute attack stage. It is our opinion that the latent interval is probably necessary for the development of sensitized lymphocytes while the localization of these cells in the CNS occurs during the active disease. Finally, the clinical and experimental observations are compatible with the hypothesis of T-cell migration into the CNS from the peripheral compartement during the active stages of MS and CR-EAE.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

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