Naslov
Platelet serotonin and monoamine oxidase activity in patients with early-onset and late-onset of Alzheimer's disease

Autori
Mimica, Ninoslav ; Muck-Šeler, Dorotea ; Pivac, Nela ; Mustapić, Maja ; Folnegović-Šmalc, Vera

Izvornik
Periodicum biologorum (0031-5362) 107 (2005), 2; 211-215

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
platelets; serotonin; monoamine oxidase; Alzheimer's disease; dementia; early-onset; late-onset

Sažetak
Post mortem brain studies indicated that serotonin (5-HT) could be involved in the ethiology of Alzheimer's disease (AD). The aim of the study was to determine platelet 5-HT concentration and platelet monoamine oxidase type B (MAO-B) activity in patients with early- and late-onset AD and in healthy subjects. The diagnosis of the probable Alzheimer's disease (NINCDS-ADRDA criteria) was established according to the ICD-10 and DSM-IV-TR criteria. Cognitive function was evaluated using Mini Mental Status Examination (MMSE). The study included 52 patients with AD (23 men ; 29 women) and 75 healthy controls (36 men ; 39 women). The symptoms of early-onset AD and late-onset AD were observed in 27 and 25 AD patients, respectively. Platelet 5-HT concentration and platelet MAO-B activity were determined spectrofluorimetrically. Patients with early-onset AD had similar platelet 5-HT values as sex-matched patients with late-onset AD and healthy controls. Significant difference in platelet MAO-B activity was observed between groups, with higher platelet MAO-B activity in male and female patients with AD than in corresponding healthy controls. A significant difference in platelet MAO-B activity was found between patients with early- and late-onset AD and healthy controls. The highest values of platelet MAO-B activity were found in both male and female patients with late-onset of AD when compared to corresponding healthy controls. The results from our preliminary, ongoing study, support the presumption that platelet MAO-B activity could be used as a biological marker for different categories of AD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

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