Pregled bibliografske jedinice broj: 186244
Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6
Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6 // Science, 288 (2000), 5473; 2045-2047 doi:10.1126/science.288.5473.2045 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 186244 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6
Autori
Volarević, Siniša ; Stewart, Mary J. ; Ledermann, Birgit ; Zilberman, Frederic ; Terracciano, Luigi ; Montini, Eugenio ; Grompe, Markus ; Kozma, Sara C. ; Thomas, George
Izvornik
Science (0036-8075) 288
(2000), 5473;
2045-2047
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
ribosomal protein S6 ; cell growth ; cell proliferation ; Cre/loxP
Sažetak
Because ribosome biogenesis plays an essential role in cell proliferation, control mechanisms may have evolved to recognize lesions in this critical anabolic process. To test this possibility, we conditionally deleted the gene encoding 40S ribosomal protein S6 in the liver of adult mice. Unexpectedly, livers from fasted animals deficient in S6 grew in response to nutrients even though biogenesis of 40S ribosomes was abolished. However, liver cells failed to proliferate or induce cyclin E expression after partial hepatectomy, despite formation of active cyclin D-CDK4 complexes. These results imply that abrogation of 40S ribosome biogenesis may induce a checkpoint control that prevents cell cycle progression.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
