Naslov
Development and validation of HPLC methods for the enantioselective analysis of bambuterol and albuterol

Autori
Bartolinčić, Anamarija ; Drušković, Vinka ; Šporec, Anita ; Vinković, Vladimir

Izvornik
Journal of pharmaceutical and biomedical analysis (0731-7085) 36 (2004); 1003-1010

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Chiral separation; Antiasthmatic drugs; Albuterol; Bambuterol; Chiral columns

Sažetak
Suitable HPLC methods for the direct separation of bambuterol and albuterol enantiomers were developed. The enantioseparation was tested on numerous commercial chiral HPLC columns. For bambuterol the most convenient separation was determined on amylose Chiralpak AD column, and for albuterol on vancomycine Chirobiotic V column. The mobile phase compositions were systematically studied to obtained the optimal chromatographic methods. Validation of methods in selected conditions shows that the chosen methods are selective and precise with linear response of detector for both pairs of enantiomers.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA