Naslov
Effect of a 17-Member Azalide on Tumor Cell Growth
(Effect of a 17-member azalide on tumor cell growth)

Autori
Grdiša, Mira ; Lopotar, Nevenka ; Pavelić, Krešimir

Izvornik
Chemotherapy (Basel) (0009-3157) 44 (1998); 331-336

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Azalide; Macrolide; Antitumor activity; Apoptosis
(azalide; macrolide; antitumor activity; apoptosis)

Sažetak
The action of the 17-member azalide 4'-demycarosyl-20-deoxo-20-(di-N-benzylamino)-8a-aza-8a-homotylosin was examined in vitro using five different human cell lines: laryngeal carcinoma (Hep2), pancreatic carcinoma (MiaPaCa2), breast carcinoma (MCF7), neuroblastoma, and normal diploid fibroblast (Hef522). After exposure, the cell growth was arrested, and morphological changes occurred in a dose-dependent manner. At a concentration of 10(-4) M the azalide completely inhibited the growth of all cell lines examined and induced morphological changes such as cell shrinkage, chromatin condensation, and DNA fragmentation. These features point to apoptosis.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA