Naslov
Serotonin transporter 5HTTLPR polymorphism and affective disorders : no evidence of association in a large European multicenter study

Autori
Mendlewitz, J. ; Massat, I. ; Souery, D. ; Del-Favero, J. ; Oruč, Lilijana ; Noethen, M.N. ; Blackwood, D. ; Muir, W. ; Battersby, S. ; Lerer, B. ; Segman, R.H. ; Kaneva, R. ; Serretti, A. ; Lili, R. ; Lorenzi, C. ; Jakovljević, Miro ; Ivezić, Slađana ; Rietschel, M. ; Milanova, V. ; Van Broeckhoven, C.

Izvornik
European journal of human genetics (1018-4813) 12 (2004), 5; 377-382

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
unipolar affective disorders; bipolar affective disorders; candidate genes; serotonin neurotransmission; Slc6a4 gene; 5-httlpr polymorphism; association study

Sažetak
The available data from preclinical and pharmacological studies on the role of the serotonin transporter (5-HTT) support the hypothesis that a dysfunction in brain serotonergic system activity contributes to the vulnerability to affective disorders (AD). 5-HTT is the major site of serotonin reuptake into the presynaptic neuron, and it has been shown that the polymorphic repeat polymorphism in the 5-HTT promotor region (5-HTTLPR) may affect gene-transcription activity. 5-HTT maps to chromosome 17 at position 17q11.17-q12, and the 5-HTTLPR polymorphisms have been extensively investigated in AD with conflicting results. The present study tested the genetic contribution of the 5-HTTLPR polymorphism in a large European multicenter case-control sample, including 539 unipolar (UPAD), 572 bipolar patients (BPAD), and 821 controls (C). Our European collaboration has led to efforts to optimize a methodology that attenuates some of the major limitations of the case-control association approach. No association was found with primary psychiatric diagnosis (UPAD and BPAD) and with phenotypic traits (family history of AD, suicidal attempt, and presence of psychotic features). Our negative findings are not attributable to the lack of statistical power, and may contribute to clarify the role of 5-HTTLPR polymorphism in AD.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA