Naslov
Simultaneous expression of CD4 and CD8 antigens by a substantial proportion of resting porcine T lymphocytes

Autori
Saalmuller, A. ; Reddehase, Mathias ; Buhring, H.J. ; Jonjić, Stipan ; Koszinowski, H. Ulrich

Izvornik
European journal of immunology (0014-2980) 17 (1987), 9; 1297-1301

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CD4 T lymphocytes ; CD8 T lymphocytes ; resting T lymphocytes

Sažetak
The existence of four subpopulations in resting porcine T lymphocytes is documented. In addition to the two known subpopulations which are typified by a mutually exclusive expression of either the CD8 or the CD4 differentiation antigen, CD4-CD8+ and CD4+CD8- T lymphocytes, respectively, two unusual subpopulations were prominent not only in peripheral blood, but also in lymphoid tissues: CD4-CD8- T lymphocytes expressing neither of these antigens and CD4+CD8+ T lymphocytes coexpressing both antigens. While CD4+CD8+ lymphoblasts have been found also in other species, resting T lymphocytes with that phenotype are without precedent among all species analyzed to date. This unique composition of the porcine T lymphocyte population has to be taken into consideration when the swine is used as a large animal model in experimental medicine.

Izvorni jezik
Engleski

POVEZANOST RADA