Pregled bibliografske jedinice broj: 183708
Immunomodulatory drugs and galectin-3
Immunomodulatory drugs and galectin-3 // 2nd Scientific Symposium with International Participation '45 years of molecular biology in Croatia - 50 years of double helix', Book of Abstracts / Ambriović Ristov, Andreja ; Brozović, Anamarija (ur.).
Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2003. (poster, nije recenziran, sažetak, znanstveni)
CROSBI ID: 183708 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Immunomodulatory drugs and galectin-3
Autori
Dabelić, Sanja ; Dumić, Jerka ; Flögel, Mirna
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
2nd Scientific Symposium with International Participation '45 years of molecular biology in Croatia - 50 years of double helix', Book of Abstracts
/ Ambriović Ristov, Andreja ; Brozović, Anamarija - Zagreb : Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2003
Skup
2nd Scientific Symposium with International Participation '45 years of molecular biology in Croatia - 50 years of double helix'
Mjesto i datum
Zagreb, Hrvatska, 20.11.2003. - 21.11.2003
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
galectin-3; immunomodulatory drugs; expression
Sažetak
Galectin-3, a 29-32 kDa lectin that specifically binds to  -galactose on glycoproteins, has been implicated in process of adhesion, in regulation of cell growth, maturation of pre-mRNA, and in apoptosis. However, its precise physiological role is still unknown. Changes in galectin-3 level were found during embriogenesis, activation of immune cells and neoplastic transformation. Binding sequences for many transcription factors were found in promotor region of LGALS-3 (i.e. galectin-3 gene). Recent studies showed that various stimuli affect galectin-3 expression and that the involvement of particular transcription factor in galectin-3 regulation depends on the type of the stimuli. So far, the effects of immunomodulatory drugs on protein glycosylation and/or regulation and expression of lectins have not been studied. Some immunomodulatory drugs activate or inhibit transcription factors that, among others, bind to the promoter regions of LGALS-3. Therefore, the aim of our study in progress is to determine the effects of steroid (hydrocortisone and dexamethasone) as well as non-steroid immunomodulatory drugs (acetylsalicylic acid and indomethacin) on expression of LGALS-3, subcellular distribution and expression of galectin-3, as well as expression and glycosylation of integrin CD11b/CD18, a galectin-3 ligand. The results of these studies would contribute to the better understanding of physiological role of galectin-3 and expand the knowledge about the mechanisms of action of immunomodulatory drugs needed for development of new therapeutical procedures.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
