Naslov
Proceedings of the 25-th International Conference on Information Technology Interfaces

Autori
Kurtanjek, Zelimir

Ostali urednici
Budin, Leo ; Luzar-Stiffler, Vesna ; Bekic, Zoran ; Hljuz-Dobric, Vesna

Vrsta, podvrsta i kategorija knjige
Autorske knjige, zbornik, znanstvena

Izdavač
Sveučilišni računski centar Sveučilišta u Zagrebu (Srce)

Grad
Zagreb

Godina
2003

Stranica
489-495

ISBN
953-96769-6-7

Ključne riječi
cell model; stochastic simulation; metabolic control

Sažetak
Proposed is a generic single gene cell model as an extension of a “ standard” single enzyme (Monod) model. The model is structured at three levels: 1) gene transcription, 2) enzyme synthesis, 3) metabolite and protein production. It accounts for a limiting substrate consumption, metabolite and biomass component production, gene transcription and enzyme synthesis. Assumed are control interactions between key components at each level based on catalytic effects. Simulated is induction of gene transcription and enzyme synthesis as a cell response to step change of extracellular medium composition. In view of small number of key molecules stochastic simulation is applied.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

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