Naslov
Monitoring of fibrinolysis parameters during myocardial revascularization according to type of procedure

Autori
Živković, Marcela ; Brkić, Kristina ; Nikić, Nada ; Hašperger, Dragica ; Juriček, Jasna ; Husedžinović, Ino ; Sutlić, Željko

Izvornik
Clinical chemistry and laboratory medicine (1434-6621) 43 (2005), 1; 43-48

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cardiopuilmonary bypass; D-dimers; fibrinolysis; PAI-1; plasminogen

Sažetak
The aim of the study was to assess the effect of cardiothoracic surgery on the dynamics of plasminogen, D-dimers and PAI-1 during first 24 hours after surgery. Study included 14 patients operated with (on-pump) and 14 without (off-pump) the use of ECC. Blood sampling was performed upon induction of anesthesia (1), introduction of heparine (2) and protamine (3), at the end of surgery (4), and next morning (5). // Relative to point 1, the utilization of plasminogen at point 2 was 24% and 17% in the on-pump and off-pump group, respectively (p=0.001 both). Increased D-dimer connectration from baseline was more pronounced in the on-pump group (p=0.001). At point 5, D-dimer concentrations were comparable in both groups and different from baseline levels. PAI-1 activity showed within group differences from baseline at point 5 in the off-pump group (p=0.001), and at point 3 and 5 in the on-pump group (p=0.002 ; p=0.001, respectively). At point 5, the activity of PAI-1 was comparable in both groups, yielding p=0.001 versus baseline. //Fibrinolysis was more pronounced and more dynamic in on-pump group due to systemic inflammatory response induced by the use of ECC. In off-pump group, fibrinolysis was a normal physiologic response to surgery procedure.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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