Naslov
Effects of combined treatment with etidronate, nadrolone-decanoate and calcium on bone mineral density in postmenopausal women

Autori
Bolanča, Slobodanka ; Koršić, Mirko ; Dekanić, Darinka ; Cvijetić, Selma

Izvornik
Acta Medica Croatica (1330-0164) 52 (1998); 159-163

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bone mineral density; calcium; combined therapy; etidronate; nandrolone-decanoate; postmenopausal women

Sažetak
The objective of this retrospective study was to see whther the effect on bone mineral density (BMD) and response to the intermittent cyclic treatment with etidronate (E) + nandrolone-decanoate (ND + calcium (Ca) (group A - combined regimen - 400 mg E daily for 2 weeks, followed by 500 mg Ca daily for the next 10 weeks + 50 mg ND once a month i.m. for 3 months in every other E caycle) was of greater benefit than cyclic E + Ca treatment (group B - standard regimen - E+Ca given in the same manner as in group A) or Ca treatment alone (group C - calcium regimen - 500 mg daily, continuously for 1 year). Group A comprised 30, group B 27 and group C 26 postmenopausal women with spinal BMD >/= 1 standard deviation below young adult mean (T score </=1) without vertebral fractures. BMD was measured by dual energy X-ray absorptiometry in the lumbar spine and femoral neck before (baseline values) and after one year treatment period. A similar, statistically significant increase in BMD was noted at lumbar spine in groups A and B (3.6% and 3.8%, respectively) and at femoral neck in groups A and B (1.7% and 2.5%, respectively). In group C, the bone loss at lumbar spine was prevented but no significant increase was recorded (0.3%) and at femoral neck an insignificant decrease in BMD was recorded (-0.3%). Percentages of change from baseline were significantly higher in groups A and B in respect to those in group C but there were no significant differences between groups A and B at lumbar spine or at femoral neck. In about 30% of women from groups A and B, spinal BMD increased by more than 4.2% ("real" responders to given therapy). A femoral BMD increase of more than 5.6% was recorded in about 13% of women from groups a and B. In group C, no such increase was recorded. In conclusion, combined intermittent cyclical regimen of E + ND has not proven to be superior to the intermittent cyclic regimen of E and Ca.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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