Naslov
Supplementation with antioxidants in the treatment of Graves' disease: the effect on the exstracellular antioxidative parameters

Autori
Bačić Vrca, Vesna ; Škreb, Franjo ; Čepelak, Ivana ; Mayer, Ljiljana

Izvornik
Acta pharmaceutica (1330-0075) 54 (2004), Xx; 79-89

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Graves disease; antioxidants; ferritin; TAS; transferrin; urates

Sažetak
In this study, the effect of supplementation with a fixed combination of antioxidants (vitamins C and E, ß-carotene and selenium) on concentrations of antioxidative parameters in serum was monitored. Measurements were performed prior to the commencement of therapy and after 30 and 60 days in patients with Graves´ disease treated with methimazole. Patients who received extra supplementation with antioxidants (group A, n = 29) attained euthyroidism faster than the patients treated only with methimazole (group B, n = 28). Statistically significant differences were achieved after supplem entation with antioxidants for all investigated parameters (uric acid, transferrin, ferritin), except TAS and glucose. Nevertheless, due to the fact that all measured parameters remained within the range of referent values, they may not be proposed as reliable indicators of the level of oxidative stress in Graves´ disease.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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