Naslov
Genetic Instabilities of the E-cadherin gene (CDH1) in renal cell carcinoma

Autori
Pećina-Šlaus, Nives ; Gall-Trošelj, Koraljka ; Radić, Krešimir ; Pavelić, Krešimir ; Pavelić, Jasminka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the The 12th Ljudevit Jurak International Symposium on Comparative Pathology / - Zagreb, 2001

Skup
Ljudevit Jurak International Symposium on Comparative Pathology (12 ; 2001)

Mjesto i datum
Zagreb, Hrvatska, 01.06.2001. - 02.06.2001

Vrsta sudjelovanja
Plenarno

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
E-cadherin gene; RCC; LOH

Sažetak
The role of tumor suppressor gene E-cadherin, CDH1 was investigated in renal cell carcinoma (RCC). D16S752 marker linked to E-cadherin gene (informativeness 91%) revealed 3 (7, 5%) LOH cases. Interestingly, in 9.1% of RCC samples replication error phenotype (RER+) was detected. Our results suggest that alterations in E-cadherin gene, are involved in evolution and progression of RCC. Microsatellite genetic instability of the E-cadherin gene indicates that another cellular mechanism, mismatch repair, may also be targeted in RCC.

Izvorni jezik
Engleski

POVEZANOST RADA