Pregled bibliografske jedinice broj: 176345
Treatment of alzheimer's disease with stabilized oral nicotinamide adenine dinucleotide: a randomized, double-blind study
Treatment of alzheimer's disease with stabilized oral nicotinamide adenine dinucleotide: a randomized, double-blind study // Drugs under experimental and clinical research, 1 (2004), 27-33 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 176345 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Treatment of alzheimer's disease with stabilized oral nicotinamide adenine dinucleotide: a randomized, double-blind study
Autori
Demarin, V. ; Podobnik Sarkanji, S. ; Storga-Tomic, D. ; Kay, G.
Izvornik
Drugs under experimental and clinical research (0378-6501) 1
(2004);
27-33
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Alzheimer's disease; Stabilized oral nicotinamide
(Alzheimer's disease; stabilized oral nicotinamide)
Sažetak
This study was designed to evaluate the etfect of stabilized oral reduced nicotinamide adenine dinucleotide (NADH) on cognitive functioning in patients with Alzheimer's disease (AD). NADH is a coenzyme that plays a key role in cellular energy production and stimulates dopamine production. In previous trials NADH has been shown to improve cognitive functioning in patients with Parkinson's disease, depression and AD. The present trial was a randomized, placebo-controlled, matched-pairs, double-blind, 6-month clinical study Patients with probable AD (n = 26) were randomized to receive either stabilized oral NADH (10 mg/day) or placebo. Twelve pairs of subjects were matched for age and baseline total score on the Mattis Dementia Rating Scale (MDRS) and the Mini Mental State Examination. Alter 6 months of treatment, subjects treated with NADH showed no evidence of progressive cognitive deterioration and had significantly higher total scores on the MDRS compared with subjects treated with placebo (p = 0.05). Analysis of MDRS subscales revealed significantly better performance by NADH subjects on measures of verbal fluency (p = 0.019), visual-constructional abiliiy (p = 0.038) and a trend (p = 0.08) to better performance on a measure of abstract verbal reasoning. There were no differences between groups in measures of attention, memory, or in clinician ratings of dementia severity (Clinical Dementia Rating). Consistent with earlier studies, the present findings support NADH as a treatment for AD.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE