Naslov
Ochratoxin A induces changes of the amount of Hsp 70 in rat liver and kidney

Autori
Barišić, Karmela ; Marinović, Adriana ; Petrik, Jozsef ; Čepelak, Ivana ; Radić, Božica ; Peljnjak, Stjepan ; Žanić-Grubišić, Tihana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Zbornik sažetaka Godišnjeg sastanka hrvatskih biokemičara / - Zagreb : Hrvatsko biokemijsko društvo, 1996, 59-59

Skup
Svečani sastanak hrvatskih biokemičara

Mjesto i datum
Zagreb, Hrvatska, 18.10.1996. - 19.10.1996

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
ochratoxin A; heat-shock protein; Hsp 70; liver; kidney; rat

Sažetak
We have examined the effects of ochratoxin A (OA) on the expression of heat-shock protein (Hsp 70), a member of highly conserved group of intracellular proteins whose synthesis is increased in response to variety of stress stimuli. Fisher rats were treated by two different doses of OA: 120 mikrograms/kg b.w./day for 10 days (group A, n=8) and for 35 days (group B, n=8), and 1200 mikrograms/kg b.w./day for 10 days (group C=8). The control group (group K) was represented by 8 untreated rats. Hsp 70 has been detected in liver and kidney homogenates by SDS-Page followed by immunoblotting using specific mAb agains Hsp 70 family. OA induced changes of the amount of Hsp 7o in both tissues, liver and kidney. In liver we detected the decrease of Hsp 70, that was dose/ and time/ dependent. In contrast to liver, in kidney it was found dose and time-dependent increase of Hsp 70. The role of heat-shock response to OA in prevention of the development of pathological changes related to OA exposure is subject to further studies.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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