Naslov
Distal polyneuropathy in normotensive type 1 diabetic patients

Autori
Vučković-Rebrina, Sandra ; Duvnjak, Lea ; Barada, Ante ; Car, Nikica ; Reljanović, Miroslav ; Metelko, Željko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Neurology (0340-5354) 249 (2002) ; 147 / - , 2002, 147-147

Mjesto i datum
,

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
type 1 diabetes; autonomic neuropathy; distal polyneuropathy

Sažetak
The aim of this study was to establish predictive factors for distal symmetric diabetic polyneuropathy (DSDP) in normotensive normoalbuminuric type 1 diabetic patients. Based on the evaluation of neurological symptoms and signs of DSDP, 110 patients were divided into two groups: patients with DSDP (G1, n=40) and those without DSDP (G2, n=70). Performing a battery of standard Ewing tests (heart rate variation at rest, during deep breathing, Valsalva ratio, 30/15 ratio, blood pressure response to standing up) and power spectral analysis of heart rate variation, autonomic neuropathy was diagnosed in 36 patients (33%). Among those, autonomic neuropathy was found in 22 patients from G1 (61.1%) and 14 from G2 (38.9%), (p<0.01). DSDP further correlated with age (G1=39.7y. ; G2=31.3y. ; p<0.0001), longer diabetes duration (G1=16.6y. ; G2=7.0y. ; p<0.0001), higher mean overnight systolic (G1=111.0mmHg ; G2=105.5mmHg ; p=0.004), diastolic (G1=65.8mmHg ; G2=59.9mmHg ; p=0.0001) and mean daily diastolic pressure (G1=76.6mmHg ; G2=72.4mmHg ; p=0.002). There were no differences between the groups in gender, body mass index, albuminuria and HbA1c. Using multiple regression analysis longer diabetes duration, higher diastolic blood pressure at night and positive power spectral analysis were independently related to the presence of DSDP. We conclude that the prevalence of distal diabetic polyneuropathy increases with age, diabetes duration, blood pressure elevation and the existence of autonomic neuropathy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA