Naslov
Botulinum toxin type a in rat model of peripheral neuropathy

Autori
Bach-Rojecky, Lidija ; Relja, Maja ; Lacković, Zdravko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
7th Congress of the European Society for Clinical Neuropharmacology ; u: Journal of Neural Transmission 111 (2004) 5 ; 145 / Riederer, Peter - Beč : Springer, 2004, 46-46

Skup
Congress of the European Society for Clinical Neuropharmacology (7 ; 2004)

Mjesto i datum
Trst, Italija, 05.05.2004. - 09.05.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
botulinum toxin; pain; nociception

Sažetak
Over the last 20 years BTX-A has been used for treating a variety of disorders characterized by increased muscle contraction and recently few clinical observations on several patients indicated that it might be useful in neuropathic pain. However up to now preclinical nociceptive action of BTX-A has been investigated in only few studies employing formalin and capsaicin tests. Here we report on the efficacy of BTX-A in rat models of neuropathic pain. After dose-response and time-course experiments performed with BTX-A using formalin and carrageenan to provoke acute pain associated with inflammation, the effectiveness of BTX-A on chronic neuropathic pain was tested. Peripheral neuropathy was evoked by partial sciatic nerve transection. Animals which developed neuropathic pain showed increased sensitivity to thermal and mechanical stimuli and were included in further investigation and treated with BTX-A. The results of present experiments show that peripherally administered BTX-A produces analgesic effect in formalin test that seems not to be clearly dose-dependent. The analgesic effect becomes significant on day 5 following toxin’s application in the rat paw pad and lasts for 30 days. However, peripherally applied BTX-A has also found to be effective in peripheral neuropathy reducing the enhanced sensitivity to pain stimuli. This study, for the first time, in experimental animals demonstrated the efficacy of BTX-A in treating experimental peripheral neuropathic pain.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Doi: 10.1007/s00702-004-0132-0

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