Naslov
Amino acids involved in the inhibition of acetylcholinesterase and butyrylcholineesterase by Ro 02-0683 and bambuterol
(Amino acids involved in the inhibition of acetylcholinesterase and butyrylcholinesterase by Ro 02-0683 and bambuterol)

Autori
Kovarik, Zrinka ; Škrinjarić-Špoljar, Mira ; Grgas, Branka ; Radić, Zoran ; Simeon-Rudolf, Vera

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Esterases reacting with organophosphorus compounds;Programme and abstracts / Reiner, Elsa - Zagreb : IMI, 1998

Skup
Third International Meeting on Esterases reacting with organophosphorus compounds

Mjesto i datum
Dubrovnik, Hrvatska, 15.04.1998. - 18.04.1998

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
inhibition of acetylcholinesterases; bambuterol
(inhibition of acetycholinesterases; bambuterol)

Sažetak
In order to indentify amino acids involved in interaction of acetylcholinesterase and butyrylcholinesterase with Ro 02-0683 the time course of inhibition by these two carbamates was studied. Bambuterol was a better and Ro 02-0683 was a worse inhibitor of the choline binding site mutant tyrosine(337)alanine(Y337A)than of the wild-type AChE.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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