Naslov
Spectroscopic and biological study of Pd(II) complexes with monoethyl 2-quinolylmethylphosphonate

Autori
Tušek-Božić, Ljerka ; Furlani, Ariella ; Scarcia, Vito

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Proceedings of the 3rd European Conference on Bio-Inorganic Chemistry / Feiters, M. C ; Hagen, W. R ; Veeger, C. - Nijmegen : NSR Center, Nijmegen, 1996, B47-B47

Skup
Third European Conference on Bio-Inorganic Chemistry

Mjesto i datum
Noordwijkerhout, Nizozemska, 04.08.1996. - 10.08.1996

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
palladium(II) complex; quinolylmethylphosphonate; spectral study; antitumor activity

Sažetak
Continuing our research on palladium complexes with organophosphorus chelate ligands, the synthesis as well as some spectroscopic and biological properties of the molecular and ionic palladium(II) complexes with the monoethyl 2-quinolylmethylphosphonate (2-mqmp) have been reported. Dihalogenopalladium complexes containing N-bonded monodentate ligand in a trans square-planar fashion were obtained by interaction of 2-mqmp with PdX_4^2- (X=Cl, Br) either in the methanolic or in the aqueous medium at pH~3.5. The neutral complex where 2-mqmp acts as a bidentate chelate ligand through the quinoline nitrogen and the phosphonic acid group was isolated at pH~6. From the HX acidic medium were isolated the ion-pair salt complexes containing the protonated quinoline ligand as cation and the trihalogenopalladium complex as anion. The in vitro cytostatic activity of all the complexes was evaluated against an epidermoid human carcinoma (KB) and against murine leukeamia (L1210) cell lines.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA