Naslov
Hydrogen peroxide modulation of the superoxide anion production by stimulated neutrophils

Autori
Dekaris, Iva ; Marotti, Tanja ; Sprong, R.C. ; Van Oirschot, J.F.L. ; Van Asbeck, B.S.

Izvornik
Immunopharmacology and immunotoxicology (0892-3973) 20 (1998), 1; 103-117

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
hydrogen peroxide; LPS; sepsis

Sažetak
Hydrogen peroxide (H2O2) pretreatment of human neutrophils results in a suppression of the superoxide anion (O2-) production in response to surface-acting stimulants such as lipopolysaccharide (LPS) and opsonized zymosan. This effect was not observed when phorbol myristate acetate (PMA), formyl-methionyl-leucyl-phenylalanine (fMLP) or tumor necrosis factor alfa (TNF alfa) were used as a stimuli. Since the response to PMA and other stimuli was unimpaired by preincubation with H2O2, we assume that the H2O2 modulated O2- production is probably due to alteration of the LPS receptor confirmation rather than effecting directly NADPH-oxidase. The balance of rective oxygen species (ROS) produced by neutrophils in the state of sepsis may thus be autoregulated by negative feedback phenomena of locally produced H2O2.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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