Naslov
Immunological reactivity in recurrent aphthous ulcerations

Autori
Cekić-Arambašin, Ana ; Juras, Danica ; Lazić, Biserka ; Klemenčić, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of 7th biennal congress of European Association of Oral Medicine / Reichart P. - Berlin : Quintessenz Verlags-GmbH, 2004

Skup
7th biennal congress of European Association of Oral Medicine

Mjesto i datum
Berlin, Njemačka, 23.09.2004. - 25.09.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cellular immunity; recurrent aphthous ulcerations

Sažetak
The aim of the present study was to analyse the cellular immunity status in patients suffering from recurrent aphthous ulcerations (RAU). Phagocytic functions, citotoxicity of natural killer cells (NK) and T-lymphocyte subpopulations were studied in the peripheral blood of 66 patients (38 female and 28 male ; age range, 8-80 years ; mean age, 42 years) with acute stage RAU, and 59 age/sex-mached healthy subjects. 67% of the patients had minor, 18% herpetiform and 15% maior ulcer types. The immunological parameters of the RAU patients, were significantly decreased in comparison with healthy subjects: spontaneus migration (P<0.0001), ingestion (P<0.0001), antibody-dependent cell-mediated cytotoxicity (ADCC) (P<0.005), NK activity (P<0.001), total T-lymphocyte (CD3+) (P<0.01) and B-lymphocytes (CD19+) percentages (P<0.001). There was no significant difference in digestion, the percentages of T-suppressor (CD8+) and T-helper (CD4+) lymphocytes between patients and controls. The results show that RAU patients have an imbalance in many parameters of cellular immunity. This study confirms that suppression of cellular immunity is important in the pathogenesis of RAU.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina

POVEZANOST RADA