Naslov
Ctogenetic aberrations in acute myeloid leukemia of childhood

Autori
Petković, Iskra ; Nakić, Melita ; Konja, Josip ; Petković, Giorgie

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Mjesto i datum
,

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Chromosome; aberrations; acute leukemia; children

Sažetak
Acute myeloid leukemia (AML) is a heterogeneous group of disease involving differences in cell morphology, immunophenotype, clinical response to the treatment, and cytogenetic abnormalities. In this work we present the results of cytogenetic analysis in 35 children with acute myeloid leukemia. The aim of our investigations was to determine the frequency and types of clonal chromosomal rearrangements in our population of children with AML. The investigation was performed on slides obtained from a 24-hour peripheral blood or bone marrow cultures. For chromosome identification GTG- and CBG- banding method were used. A successful analysis was obtained in 32 (91.4%) children. In 30 children the analysis was performed at diagnosis and in two at relapse. Clonal chromosomal aberrations were detected in 19 (63.3%) children at diagnosis. The most frequent clonal abnormality was t(8 ; 21) identified in 6 (20%) patients, followed by aberrations involving chromosome 11 in 4 (13.3%) cases. Trisomy 8 was identified in two and monosomy 7 in one patient. Beside these recurrent abnormalities some non-specific rearrangements were identified too. This study confirms the cytogenetic heterogeneity of AML, and need for additional study in order gain more information on clonal chromosomal rearrangements and its clinical significance.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA