Naslov
Coronavirus-induced encephalomyelitis: balance between protection and immune pathology depends on the immunization schedule with spike protein S

Autori
Flory, Egbert ; Barac-Latas, Vesna ; Lassmann, Hans ; Wege, Helmut

Izvornik
Journal of general virology (0022-1317) 76 (1995); 873-879

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
encephalomyelitis ; neurotropic mouse hepatitis virus ; Lewis rats

Sažetak
The neurotropic mouse hepatitis virus MHV-JHM induces central nervous system (CNS) demyelination in Lewis rats that pathologicaly resembles CNS lesions in multiple sclerosis. The mechanisms of MHV-JHM-induced demyelination remains unclear and several studies have implicated the role of the immune response in the process. We have shown previously that protective immunity against MHV- JHM-induced encephalomyelitis was induced by immunization with a vaccinia virus (VV) recombinant expressing MHV-JHM S-protein (VV-S). Here, we present evidence that the time of MHV-JHM challenge after immunization with VV-S plays a critical role in protective immunity. The induction of virus-neutralizing S-protein-specific antibodies prior to the MHV-JHM challenge modulates the disease process and a subacute encephalomyelitis based on a persistant virus infection developed. Typical pathological alterations were lesions of inflammatory demyelination. In addition, the results indicate that after seroconversion, CD8+ T cells were no longer essential for virus elimination in contrast to their rolre in protection during acute encephalomyelitis.

Izvorni jezik
Engleski

POVEZANOST RADA