Naslov
Developmental and behavioral effects of prenatal atrazine and deethylatrazine exposure on rats

Autori
Peruzović, Marijana ; Kniewald, Jasna ; Čapkun, Vesna ; Milković, Karmela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Zbornik sažetaka 8. hrvatskog biološkog kongresa s međunarodnim sudjelovanjem, Zagreb, Hrvatska, 27. rujan - 2. listopad 2003. / - Zagreb : Hrvatsko biološko društvo, 2003, 369-370

Skup
8. Hrvatski biološki kongres s međunarodnim sudjelovanjem

Mjesto i datum
Zagreb, Hrvatska, 27.09.2003. - 02.10.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
atrazine; deethylatrazine; developmental effects; behavioral effects; rat

Sažetak
The effects of the herbicide atrazine as well as of its metabolite deethylatrazine were investigated on the Fischer rat females and on their offspring. Twenty one doses of atrazine 16.6 mg/kg, s.c. in 0.1 ml of paraffin oil were injected daily to the pregnant females in Group A (A). Deethylatrazine Group (DA) received in the same way 16.6 mg/kg of deethylatrazine. Control group applied paraffin oil only (CO) while Control intact group (CI) was left undisturbed. Rat females grew up with normal body weight gain throughout the pregnancy. The effect on the offspring development depended of the characteristics of the postnatal foster mothers, i.e. the intact controls (I) or treated females (II). Prenatal treatments did not have an effect on offspring body weight at birth, although elevated body weight gain during postnatal period from day 7-90 was observed in Groups A and DA vs. CO, CI p<0.05-0.01 (I). However, at the 2^nd postnatal day females of Group A were the lightest vs. CO p<0.01 (II). The extinction trials of the conditioned escape responses in the shuttle box were facilitated in 94-day old females in Group A vs. CO p<0.05, while the higher avoidance scores in both DA and CO vs. CI was p<0.05 (I). Motor coordination and physical strength in rotaroad treadmill as well as spontaneous activity in the activity cage were the same in all groups (I). However, 91-day old females of Group A had the best performance in the treadmill vs. DA, CO p<0.05, while the highest spontaneous activity showed on the 90^th day males of Group A vs. DA, CO p<0.01, and females of Group DA vs. A, CO p<0.01 (II). In conclusion the results revealed prenatal exposure to s-triazines partly interfere with postnatal weight gain as on behavior indicating that prenatal treatment had the persistent latent neurotoxic effect.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

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