Naslov
Metabolic Databases for drug-drug and drug-chemical interactions

Autori
Rendić, Slobodan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Expert Oppinion on Drug Safety / McCallum, Amy - London : Delhi : Ashley Publications, 2004, 380-380

Skup
Strategies for more reliable and effective ADME

Mjesto i datum
London, Ujedinjeno Kraljevstvo, 30.03.2004. - 31.03.2004

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
drug design; metabolic databases; metabolic enzymes and transporters; benefits and limitations

Sažetak
Presented is development and use of Human Metabolism Databases based on an approach published in: Rendic S. and DiCarlo F., Drug Metab. Rev., 29 (1&2) 413-580, 1997 and Rendic S., Drug Metab. Rev., Special issue on Human P450s, 34 (1&2) 83-448, 2002. The data on P450 enzymes were used for initial development of the metabolic databases in a format enabling quick qualitative and accurate quantitative approach to the latest data on specific interactions for a given substance (endo- or xenobiotics) with Human P450 (CYP) Enzymes, extended further to Human Transporters and supported by the Structural database. The data are designed for predicting and interpreting of the P450 metabolic data for application in drug design and development. The data have also been used to extract and analyze structural information contributing to metabolic reactions.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA