Naslov
Utjecaj lijeka isotretinoina na psihološki status bolesnika s acne vulgaris
(Isotretinoin and its influence on psychological status of patients with acne vulgaris)

Autori
Kotrulja, Lena ; Sjerobabski Masnec, Ines ; Vurnek, Maja ; Oremović, Lenka ; Šitum, Mirna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
.... : knjiga sažetaka ; u: Acta Dermatovenerologica Croatica 12 (2004) 198-199 / - , 2004, 198-199

Skup
XXX

Mjesto i datum
XX, XXX, 2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
isotretinoin ; acne vulgaris ; nuspojava ; psihološki aspekt ; depresija ; suicid
(isotretinoin ; acne vulgaris ; side-effects ; psychological aspect ; depression ; suicidedn)

Sažetak
The extent to which severe acne affects patients' personality and emotional life is still undetermined. The patients with severe acne vulgaris frequently report feeling self-conscious, anxiety and social isolation. Isotretinoin is the drug indicated for severe, recalcitrant nodular acne that has proved unresponsive to other therapies. Isotretinoin's link to psychiatric adverse events is controversial. For the last 15 years there has been debate over whether isotretinoin could be causing depression and subsequent suicide in teenagers. Though depression and suicide are important health problems for teenagers, there is as yet no good evidence that isotretinoin contributes significantly to either. Numerous clinical investigations have failed to identify an association between the use of the isotretinoin and the development of psychiatric disorders. The causal relationship between isotretinoin therapy and depression has not been clearly established and needs further study. Acne may be associated with low self-esteem and poor self-image, problems which can eventually lead to serious psychological conditions. Since isotretinoin is an effective treatment for acne, it may help reduce associated psychological disturbances. The goal of this study was to investigate the influence of isotretinoin on psychological status of acne patients during and after treatment. The following work describes the benefit of using a questionnaire as a clinical tool to identify acne patients who have developed psyhological sequelae as a result of the disease process. A sample of 50 patients (23 man and 27 women) with moderate to severe form of acne vulgaris were prospectively examined for psychological, emotional and dermatological symptomatology using a variety of standardised psychometric inventory such as DSQL, APSEA, BDI, MPS, STAI which were applied at the beginning of the therapy, as well as after 5, 10, 16 weeks and at the end of the treatment when the disease had been brought under control effectively. The subgroup of 25 patients (15 man and 10 women) has received isotretinoin taking in consideration the severe, recalcitrant form of papulopustular or nodulocystic acne. The results of this prospective clinical study show significant decrease of depression and anxiety as well as an improvement of psychosocial status and quality of life after succesful treatment in both groups of patients. The use of oral isotretinoin was very effective therapy and no influence on psychological disturbances was observed. However, monitoring patients for depression, depressive symptoms, and suicidal ideation can help identify those who may be at risk and improve patient care by facilitating appropriate diagnosis and treatment of patients experiencing clinical depression.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Psihologija

POVEZANOST RADA