Naslov
Stimulation of 5-HT1A receptors increases the seizure threshold for picrotoxin in mice

Autori
Peričić, Danka ; Lazić, Josipa ; Jazvinšćak Jembrek, Maja ; Švob Štrac, Dubravka

Izvornik
European Journal of Pharmacology (0014-2999) 527 (2005), 1-3; 105-110

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Swim stress; Convulsions; (±;;; )-8-hydroxy-2-(di-n-propylamino) tetralin hydrobromide (8-OH-DPAT); WAY-100635; 1-(2; 5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI); ketanserin

Sažetak
To evaluate the possible role of 5-HT1A and 5-HT2A receptors in the anticonvulsant effect of swim stress, mice were pre-treated with agonists and antagonists of these receptors prior to exposure to stress and the intravenous infusion of picrotoxin. 8-OH-DPAT ((&plusmn ; ; ; )-8-hydroxy-2-(di-n-propylamino)tetralin) and WAY-100635 (a selective agonist and antagonist of 5-HT1A receptors), DOI (1-(2, 5-Dimethoxy-4-iodophenyl)-2-aminopropane) and ketanserin (a 5-HT2A/2C receptor agonist and antagonist) were used. Results demonstrated that 1 and 3 mg/kg of 8-OH-DPAT increased the doses of picrotoxin producing running/bouncing clonus, tonic hindlimb extension and death in stressed and unstressed mice, respectively. Pre-treatment with WAY (0.3 mg/kg) prevented the effect of 8-OH- DPAT (3 mg/kg). DOI (2.5 mg/kg) and ketanserin (1 mg/kg) failed to affect the seizure threshold for picrotoxin. The results show that stimulation of 5-HT1A receptors exerts anticonvulsant actions in stressed and unstressed mice, while stimulation of 5-HT2A/2C receptors does not interfere with the effect of stress on picrotoxin-induced convulsions.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA