Naslov
Developmental and behavioral effect of s-triazines on rats

Autori
Peruzović, Marijana ; Čapkun, Vesna ; Kniewald, Jasna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Periodicum biologorum, Volume 106, Supplement 1, Abstracts of the Fourth Croatian Congress of Pharmacology with International Participation, September 15-18, 2004 Split, Croatia / Vitale, Branko - Zagreb : Hrvatsko prirodoslovno društvo, 2004

Skup
Fourth Croatian Congress of Pharmacology with International Participation

Mjesto i datum
Split, Hrvatska, 15.09.2004. - 18.09.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
atrazine; developmental effects; behavioral effects

Sažetak
Atrazine, a selective s-triazine herbicide, is the most commonly used herbicide in the U.S. and probably the World. Previous studies have suggested that atrazine is an endocrine disruptor in mammals. Both, in vivo as well as in vitro administration of atrazine causes the modification of 5 alpha-reductase activity, specific 5 alpha-dihidrotesterone-receptor complex reductase, the synthesis of follicle-stimulating hormone (FSH), the estrus cycle, on onsent of puberty and body weight. Furthermore, the herbicide atrazine is biotransformed in mammals and the influence of its biodegradation product - deethylatrazine could also have influence on psychosomatic development in the rats. The long lasting possible effects of atrazine as well as of its metabolite deethylatrazine were investigated on females and on their offspring. Atrazine (16.6 mg/kg, s.c. in 0.1 ml of paraffin oil) was injected daily to the pregnant Fischer rat in Group A (A). Deethylatrazine Group (DEA) received in the same way 16.6 mg/kg of deethylatrazine. Control group applied paraffin oil only (CO) while Control intact group (CI) was left undisturbed. Rat females grew up with normal body weight gain throughout all the pregnancy. Two days old female offspring of Group A were the lightest vs. CO (p<0.01). In the adulthood the highest spontaneous activity (Activity cage, Ugo Basile, Italy, No. 7400) showed 90-days old males of Group A vs. DA and CO (p<0.01), and females of Group DA vs. A and CO (p<0.01). However, 91-day old females of Group A had the best performance in the treadmill vs. DA and CO (p<0.05 ; Rota-rod treadmill for rats, Ugo Basile, Italy, No. 7700). During acquisition trials (Automatic Reflex Conditioner, Ugo Basile, Italy, No.7501) and extinction trials the total latency time (s) and the number of active avoidance responses were the same in the treated vs. control rats in the age of 92 and 93-days. Revealed results showed of prenatal exposure to s-triazines partly interfere with postnatal weight gain as on behavior in the adult age suggesting that prenatal treatment had the persistent neurotoxic effect.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

POVEZANOST RADA