Naslov
Structural Analysis of Oligopeptides Containing Ferrocene Amino Acids as Potential Beta-turn Mimics

Autori
Barišić, Lidija ; Dropučić, Maja ; Rapić, Vladimir ; Kirin, Srećko Ivan ; Metzler-Nolte, Nils

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
13th European Symposium on Organic Reactivity : ESOC-13 : abstracts / - Zagreb, 2003

Skup
European Symposium on Organic Chemistry

Mjesto i datum
Dubrovnik, Hrvatska; Cavtat, Hrvatska, 10.09.2003. - 15.09.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
ferrocene-containing oligopeptides; beta-turn mimics; structural analysis

Sažetak
In continuation of our studies in the field of heteroannularly substituted ferrocene amino acids 1 (m, n = 0-3) and their derivatives, we reported about coupling of their N-Boc derivatives with L-alanine into oligopeptides 2 (m, n = 0-3 ; p, r = 1-2) using EDC/ HOBt protoco. A number of a ferrocene-containing oligopeptides with parallel substituting strands (NHCHRCO)n were prepared starting from 1, 1'-Fn(COOH)2 and studied as a beta-sheet models. It is worth mentioning that compounds 2 are the first example of ferrocene-containing oligomers with antiparallel strands. These conjugates containing 1, 1'-ferrocenylene unit as beta-turn inducer are expected to be better mimics of ordinary natural beta-sheets than the parallel ones. In the present work we have carried out a detailed structural study on possible interstrand contacts in oligopeptides 2. For this purposes we have analysed their IR and NMR spectra in solvents which themselves do not form hydrogen bonds.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA