Naslov
Conformational Polymorphysm and Hydrogen Bonding Patterns in Ferrocene Amino Aacid Derivatives Containing Trimethylene Spaces

Autori
Barišić, Lidija ; Pavlović, Gordana ; Rapić, Vladimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
13th European Symposium on Organic Chemistry : ESOC-13 : Book of Abstract (P1-109) / - Zagreb, 2003, 236-236

Skup
European Symposium on Organic Chemistry (13 ; 2003)

Mjesto i datum
Dubrovnik, Hrvatska; Cavtat, Hrvatska, 10.09.2003. - 15.09.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
ferrocene amino acid derivatives; hydrogen bonding; conformational polymorphism

Sažetak
As a part of our studies on heteroannularly substituted ferrocene amino acids we have recently published efficient synthesis of 1'-aminoferrocene-1-carboxylic acid (1a) and its derivatives 2a and 3a. The higher homologues 1b/1c and their N- and C-protected derivatives were prepared using the same general method via corresponding ester-azide 2. The crystal and molecular structures of derivatives 2b and 3c have been determined by the single crystal X-ray analysis.Compound 2b crystallizes in two polymorphic forms (2b' and 2b'') ; one of them (2b'') contains two crystallographically independent molecules. The molecules 2b' and 2b'' differentiate only in the conformation of (CH2)3NHAc part of the molecules exhibiting conformational polymorphism. The crystal structures are dominated by the intermolecular hydrogen bonds of the N-H...C=O type (2.820(1)A) 2.840(2)A) linking molecules into endless chains in all three structures. The chains are further interconnected by the C-H...O hydrogen bonds (3.483(1)-3.267(2) A) in 2b' and 3c, but not in 2b''.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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