Naslov
A new extended haplotype Cw*0602-B57-DRB1+0701-DQA1*0201-DQB1+0201 associated with psoriasis in the Croatian population

Autori
Kaštelan, Marija ; Gruber, Franjo ; Čečuk-Jeličić, Esma ; Grubić, Zorana ; Kaštelan, Andrija

Izvornik
Clinical and experimental dermatology (0307-6938) 28 (2003), 2; 200-202

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
psoriasis; HLA; expanded haplotype

Sažetak
In this study, we have analysed the distribution of HLA class II alleles and the extended haplotype HLA-Cw-B-DRB1-DQA1-DQB1 in Croatian patients with type I and type II psoriasis by hybridization with specific oligonucleotide probes. Type I psoriasis showed a significant association with the DRB1*0701 [P < 0.00001 ; relative risk (RR) = 5.83], DQA1*0201 (P < 0.00001 ; RR = 6.12), DQB1*0201 (P = 0.0006 ; RR = 3.29) and DQB1*0303 alleles (P = 0.0008 ; RR = 7.51). A negative correlation with type I disease was observed for the DQA1*0102 allele (P = 0.002 ; RR = 0.26). Type II psoriasis did not show any association with any class II alleles. The extended haplotype HLA-Cw*0602-B57-DRB1*0701-DQA1*0201-DQB1*0201 was present at a significantly higher frequency in type I patients (P < 0.00001 ; RR = 7.72). However, this haplotype was not detected at all in patients with type II psoriasis. In conclusion, the extended haplotype HLA-Cw*0602-B57-DRB1*0701-DQA1*0201-DQB1*0201 is a risk haplotype for type I disease in the Croatian population. This particular haplotype has not been reported previously in association with psoriasis in any other ethnic groups.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA