Naslov
Polymorphisms of the Fc_ receptor type IIB gene are not associated with systemic lupus erythematosus in the Swedish population

Autori
Magnusson, V. ; Zunec, Renata ; Odeberg, J. ; Truedsson, I. ; Alarco´n-Riquelme, Marta

Izvornik
Arthritis and rheumatism (0004-3591) 50 (2004), 4; 1348-1350

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Systemic lupus erythematosus (SLE); Fc receptor;

Sažetak
In the present study we investigated the role of Fc_RIIB in SLE susceptibility. We performed genotyping of the Fc_R2B-232I/T SNP and an additional novel SNP in the 3_-untranslated region (Fc_R2B.3-A/G) 193 bp downstream of the stop codon. The Fc_R2B.3 SNP was identified by a computer-based bioinformatics search in the dbSNP and verified to be polymorphic by direct sequencing in 16 control subjects. We conducted a case- control study with 263 female SLE cases and 228 female healthy controls. Patients and controls were all of Swedish ancestry (ethnic background was determined based on the ancestries of the great-grandparents, using a questionnaire). All patients were diagnosed by a specialist and fulfilled the American College of Rheumatology 1982 revised criteria for the classification of SLE. The distribution of alleles and genotypes was in Hardy-Weinberg equilibrium both in cases and in controls, and there was no significant difference in genotype or allele frequencies between cases and controls.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA